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2025 CTSI Pathway-to-Pilot Awards Letter of Intent Solicitation

Returning?

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Please complete the application process by providing the information requested below.

You will then be asked to upload the following: a two-page Letter of Intent (LOI) and a PI funding attestation.

No additional pages are permitted for a bibliography. Bibliographic information must be included within the two page LOI.
No letters of support are to be submitted with the LOI.

The pilot project RFA is available on the CTSI website at: https://www.urmc.rochester.edu/clinical-translational-science-institute/funding

Note: After clicking on the "Submit" button at the end of the application, you will be provided with a code that can be used to access your submitted application if you need to revise it. The version that is in the system at the submission deadline will be the final version that will be reviewed. After submitting your application, you will also be offered the opportunity to download a PDF of the application.

Title of the Project. (No acronyms are permitted.)

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Principal Investigator First Name

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Principal Investigator Last Name

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PI Department

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PI Email Address

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PI Phone

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Pathway-to-Pilot Award Category of Application (Please select the category to which you are applying.)

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Data Science

Dissemination and Implementation

UNYTE

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Name of Multiple Principal Investigator #1 or Co-Investigator #1

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

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Yes

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Name of Multiple Principal Investigator #2 or Co-Investigator #2

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

* must provide value

Yes

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Name of Multiple Principal Investigator #3 or Co-Investigator #3

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

Yes

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Name of Multiple Principal Investigator #4 or Co-Investigator #4

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

* must provide value

Yes

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Name of Multiple Principal Investigator #5 or Co-Investigator #5

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

* must provide value

Yes

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Name of Multiple Principal Investigator #6 or Co-Investigator #6

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

* must provide value

Yes

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Name of Multiple Principal Investigator #7 or Co-Investigator #7

Role

Multiple Principal Investigator

Co-Investigator

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Department

Email Address

Institution (if not URMC)

Are there additional Multiple Principal Investigators or Co-Investigators?

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Yes

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Provide the following information for each additional investigator: Name, Role, Department, Email Address, and Institution (if not URMC).

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Name of Department Administrator or Grants Administrator

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Administrator Email Address

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Amount Requested $

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Application Type

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New Application

Revised Application

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Are human subjects involved?

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Yes

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Are vertebrate animals involved?

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Yes

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Definition of a Foreign Component

In accordance with the NIH Grants Policy Statement, a foreign component is defined as performance of any significant element or segment of the project outside the United States, either by the recipient or by a researcher employed by a foreign organization, whether or not grant funds are expended. Activities that would meet this definition include, but are not limited to: the involvement of human subjects or animals; extensive foreign travel by grantee project staff for the purpose of data collection, surveying, sampling, and similar activities; or any activity of the grantee that may have an impact on U.S. foreign policy through involvement in the affairs or environment of a foreign country.

Examples of other grant-related activities that may be foreign components are: collaborations with investigators at a foreign site anticipated to result in co-authorship; user of facilities or instrumentation at a foreign site; or receipt of financial support or resources from a foreign entity.

Grant-related activity that is not considered a foreign component includes the following: 1) foreign travel exclusively for consultation and/or conference attendance; 2) conference grant (R13/U13) support of travel exclusively for conference attendance; and 3) in cases where all grant-related research is being conducted in the United States and involves a researcher or other project team member who has support from a foreign source.

Does your project involve human subjects at a foreign site?

* must provide value

Yes

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Does your project involve vertebrate animals at a foreign site?

* must provide value

Yes

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Does your project involve extensive foreign travel by project staff for the purpose of data collection, surveying, sampling, and similar activities?

* must provide value

Yes

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Does your project involve any activity that may have an impact on U.S. foreign policy through involvement in the affairs or environment of a foreign country?

* must provide value

Yes

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Does your project involve collaborations with investigators at a foreign site that are anticipated to result in co-authorship?

* must provide value

Yes

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Describe the collaboration with investigators at a foreign site that are anticipated to result in co-authorship.

* must provide value

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Does your project involve use of facilities or instrumentation at a foreign site?

* must provide value

Yes

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Describe the use of facilities or instrumentation at the foreign site.

* must provide value

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Does your project involve receipt of financial support or resources from a foreign entity?

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Yes

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Describe the receipt of financial support or resources from the foreign entity.

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Name of the first foreign country involved in your research:

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If more than one foreign country is involved in your project, please identify the activity relevant to the involvement of the first foreign country in your project.

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Is there a second foreign country involved in your project?

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Yes

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Name of the second foreign country involved in your project:

* must provide value

Please identify the activity relevant to the second foreign country involved in your project.

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Is there a third foreign country involved in your project?

* must provide value

Yes

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Name of the third foreign country involved in your project:

* must provide value

Please identify the activity relevant to the third foreign country involved in your project.

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Is there a fourth foreign country involved in your project?

* must provide value

Yes

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Name of the fourth foreign country involved in your project:

* must provide value

Please identify the activity relevant to the fourth foreign country involved in your project.

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Provide three names and e-mail addresses of suggested University of Rochester faculty reviewers who have

1) not co-authored peer-reviewed articles with the PI in the last 3 years, and
2) do not have any active grant funding with any Key Personnel in the application.

Name of Suggested Reviewer 1:

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Email Address for Suggested Reviewer 1 :

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Name of Suggested Reviewer 2:

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Email Address for Suggested Reviewer 2:

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Name of Suggested Reviewer 3:

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Email Address for Suggested Reviewer 3:

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I acknowledge and understand the following conditions that are detailed in the RFA:

The project must be funded solely with CTSI pilot funds. NIH rules do not permit supplemental funding from other sources.
The project cannot be an add-on to, or an extension of, a parent project supported by another funding source.
Funds will not be awarded to support continuation/renewal of a previously funded project.
Awards under this RFA will be for the project period of July 1, 2025 - May 31, 2026. No carryforward will be permitted.

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Yes No

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What translational barrier is your LOI addressing?

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What is your proposed solution to this barrier?

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How is this solution generalizable ( i.e. broadly applied to multiple disease states, fields of scientific inquiry, or population health equity issues)?

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Upload a Letter of Intent (limited to 2 pages in Arial 11 point font size, 0.5 inch margins) in PDF format, which includes the following:

(1) Project title and names of the PI, MPIs and co-investigators

(2) Background and Translational Significance

a. Context for the proposed research
b. The barrier in translational research, how it will be addressed, and how the identified solutions can be applied across multiple diseases, treatments, and inventions.
c. Measurable Specific Aims
e. How the proposed project would impact the speed of translational research.

(3) Research Methods

a. Feasibility
b. Source of the study data
c. Study design, including research procedures
d. Structure of the study team

SPECIAL NOTES: No additional pages are permitted for a bibliography. Bibliographic information must be included within the two-page LOI.

No letters of support are to be submitted with the LOI.

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Upload file

Upload a signed attestation statement, in PDF format, from the PI that there is no funding of the project through another mechanism.

A template for this attestation is available at https://www.urmc.rochester.edu/MediaLibraries/URMCMedia/ctsi/Funding/Pilot-Studies-Funding-Attestation-Template.doc

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Upload file

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